George Crull
NMR Facility Assistant Director
NMR Spectroscopist
Biography
Keywords
- Solid state NMR (ssNMR)
- Solution state NMR
- molecular interactions in the condensed state
- Molecular dynamics in the solid or solution state
- Pharmaceutical stability and structures
- Polymorphism
- Structure Elucidation
Research interests
- Solid-state and solution-state NMR spectroscopy of chemical, polymeric, pharmaceutical, and biological materials
- Interactions in the condensed state
- Molecular dynamics
- Structure elucidation
- NMR education
Recent publications
- Wilson, A.; Myers, C.; Crull, G.B.; Curtis, M.S.; Pasciak, P.M. “A Mentorship: Analysis of Soft Drinks using Nuclear Magnetic Resonance Spectroscopy”, Journal of Chemical Education, 1999.
- Ye, Qingmei; Xu, Zhongmin; Crull, George; Leshcninskaya, Vera; Huang, Yande; Palaniswamy, V. “Structural Determination of a Process Impurity and Control of Its Formation in Support of Development of Brivanib, An Oral Dual Inhibitor of VEGFR and FGFR Tyrosine Kinases.” Abstracts, 40th Middle Atlantic Regional Meeting of the American Chemical Society, Queens, NY, United States, May 17-21, 2008.
- Pan, D.; Crull, G.; Yin, S.; Grosso, J. “Low Level Drug Product API Form Analysis – Avalide Tablet NIR Quantitative Method Development and Robustness Challenges”, J. Pharm. Biomed. Sci., 2014, 89, 268.
- Leane, M.M.; Gamble, J.F.; Tobyn, M.; Hughes, H.; Crull, G.; Bunker, M.; Rutherford, S.; Parker, A.; Roberts, C.J.; Brown, J. “Imaging dehydration kinetics of a channel hydrate form of the HIV‐1 Attachment Inhibitor Prodrug BMS‐663068”, J. Pharm. Sci., 2013, 102, 3475.
- Abraham, A.; Crull, G. “Understanding API-Polymer Proximities in Amorphous Stabilized Composite Drug products using Fluorine-Carbon 2D HETCOR Solid-state NMR”, J. Mol. Pharm., 2014, 11, 3754.
- McNamara, Daniel; Yin, Shawn; Pan, Duohai; Crull, George; Timmins, Peter; Vig, Balvinder. “Characterization of Phase Separation Propensity for Amorphous Spray Dried Dispersions”, Molecular Pharmaceutics, 2017, 14, 377.
- Schlam, Roxana; Crull, George; Pan, Duohai; Patel, Anisha; Ng, Alicia; Gao, Qi; Sandoval, Maria. "Understanding the Effect of Hydration-State Variability on the Solid-State Characterization of a Pharmaceutical Non-Stoichiometric Hydrate", Submitted.
- Desai, Salil; Kundu, Ipsi1; Swamy, Narayana; Crull, George3; Pan, Duohai; Zhao, Junshu; Shah, Ravi; Venkatesh, Chiranjeevi; Vig, Balvinder; A. Varia, Sailesh; Badawy, Sherif; Desikan, Sridhar; Bhutani, Hemant. “Mechanistic Investigation of poly (vinyl alcohol) based Opadry® II Films Insolubilization and Effect of Processing”, Submitted.
