Periodic Table

The Nguyen group has developed new approach for the effective synthesis of biologically important 1,2-cis-2-aminosugars via nickel-catalyzed selective glycosylation. Currently, this method applies to the synthesis of heparin oligosaccharides with no binding affinity to platelet-factor-4 (PF4) while the relative binding affinity to antithrombin protein (AT) remains unchanged. The anticoagulant function results from heparin-AT interaction, while the serious complication, heparin-induced thrombocytopenia (HIT) associated with heart attack, strokes and cardiovascular-associated death, results from heparin-PF4 complexes. Our second program is to develop a rapid and efficient fluorination method for incorporation of [18F]-fluoride ion into bioactive molecules used as radiotracers in PET imaging.