Dave Martin

Dave Martin
Assistant Professor
E433 CB
  • B.Sc. in Chemistry, University of British Columbia, 2005
  • Ph.D. in Chemist, University of California, Irvine, 2011
  • Postdoc, Princeton University, 2011–2014

Catalysis, photocatalysis, radical chemistry, natural product synthesis, neuroprotection, mechanism of action studies

Research Interests: 

Research in the Martin lab focuses on the development of new catalytic transformations, novel strategies for bond activation and the synthesis of bioactive molecules for the study and treatment of human disease. We find inspiration both through the identification of bioactive natural product targets and through consideration of larger problems where organic chemistry is poised to offer practical solutions (e.g. depolymerization and selective functionalization of biomass). Our goal is to provide reaction platforms that are both practical and sustainable for a variety of synthetic applications.

Another major focus of the lab is to explore general approaches to families of natural products where promising biological activity has been reported, in particular for the study and prevention of diseases such as cancer and neurodegeneration. In addition to chemical synthesis, we are pursuing studies of their mechanism of action and initiate collaborative studies where appropriate. We currently have active collaborations with researchers in the Departments of Biochemistry, Biomedical Sciences, and the School of Medicine.

Recent Publications: 

Hai-Bin Yang, Abigail Feceu, David B.C. Martin, "Catalyst-Controlled C–H Functionalization of Adamantanes using Selective H-Atom Transfer."  ChemRxiv, 7409651.

Taylor S. Alexander, Travis J. Clay, Bryan Maldonado, Johny M. Nguyen, David B. C. Martin,"Comparative Studies of Palladium and Copper-Catalysed γ-Arylation of Silyloxy Furans with Diaryliodonium Salts" , Tetrahedron 2019, 75, 2229–2238.

Abigail Feceu§, Corey M. Griffith§, Cynthia K. Larive, David B. C. Martin,"Synthesis and Structure Reassignment of Malylglutamate, a Recently Discovered Earthworm Metabolite" J. Nat. Prod., 2019, 82, 417-421.

William K. Weigel, Taylor N. Dennis, Amrik S. Kang, J. Jefferson P. Perry, David B. C. Martin, "A Heck-Based Strategy to Generate Anacardic Acids and Related Phenolic Lipids for Isoform-Specific Bioactivity Profiling." Org. Lett., 2018, 20, 6234–6238.

Abigail Feceu, Lauren E. Sangster, David B. C. Martin. "Unexpected Alkene Isomerization During Iterative Cross-Coupling To Form Hindered, Electron-Deficient Trienes." Org. Lett. 2018, 20, 3151-3155.

Dana R. Chambers, Raymond E. Sullivan, David B. C. Martin. "Synthesis and Characterization of Alkoxycarbonyl Cobalt Complexes via Direct Carbonylation Methods." Organometallics 2017, 36, 1630-1639.

Michael T. Pirnot, Danica A. Rankic, David B. C. Martin, David W. C. MacMillan. “Photoredox Activation for the Direct beta-Arylation of Ketones and Aldehydes.” Science 2013, 339, 1593-1596. 

David B. C. Martin, Christopher D. Vanderwal. “A Synthesis of Strychnine by a Longest Linear Sequence of Six Steps.” Chem. Sci. 2011, 2, 649-651.

David B. C. Martin, Christopher D. Vanderwal. “Efficient Access to the Core of the Strychnos, Aspidosperma andIboga Alkaloids. A Short Synthesis of Norfluorocurarine.” J. Am. Chem. Soc. 2009, 131, 3472-3473.