Publications

2019

  • Stability and efficiency of mixed aryl phosphonate prodrugs. Foust, B. J.; Li, J.; Hsiao, C. C.; Wiemer, A. J.; Wiemer, D. F. ChemMedChem 2019, 14, 1597-1603.
  • Synthesis and bioactivity of the phosphonamidate stereoisomers derived from a Butyrophilin ligand. Lentini, N. A.; Hsiao, C. C.; Crull, G. B.; Wiemer, A. J.; Wiemer, D. F.  ACS Med. Chem. Lett. 2019,10, 1284–1289.   
  • ω-Hydroxy isoprenoid bisphosphonates as linkable GGDPS inhibitors.  Bhuiyan, N. H.; Varney, M. L.; Bhattacharya, D. S.; Payne, W. M.; Mohs, A. M.; Holstein, S. A; Wiemer, D. F.  Bioorg. Med. Chem. Lett. 2019, 29, in press.
  • A luciferase lysis assay reveals in vivo malignant cell sensitization by phosphoantigen prodrugs. Li, J. Lentini, N. A.; Wiemer, D. F.; and Wiemer, A. J. Biochem. Pharm. 2019, in press. 
  • Synthesis of benzimidazole phosphonate as potential inhibitors of late stage isoprenoid biosynthesis, Bhuiyan, N. H.;  Varney, M. L.; Wiemer, D. F.; Holstein, S. A. Bioorg. Med. Chem. Lett. 2019, in press.

2018

  • Phosphonamidate prodrugs of a butyrophilin ligand display extended plasma stability and potent Vγ9Vδ2 T cell stimulation.  Lentini, N. A.; Foust, B. J.; Hsiao, C. C.; Wiemer, A. J.; Wiemer, D. F. J. Med. Chem. 2018, 61,  8658–8669. PMID: 30199251
  • Chemo-enzymatic synthesis of the exocyclic olefin isomer of thymidine monophosphate. Mondal, D.; Koehn, E. M.; Yao, J.;  Wiemer, D. F.; Kohen, A. Bioorg. Med. Chem. 2018, 26, 2365-2371.  PMID: 29606487
  • Synthesis of bavachromanol from resorcinol via a tandem cationic cascade/EAS sequence. Shah, P. A.; Wiemer, D. F. Tetrahedron Lett. 2018, 59, 1363-1365.
  • Quantitative Determination of a Potent Geranylgeranyl Diphosphate Synthase Inhibitor using LC-MS/MS: Derivatization and Application, Chhonker, Y. S.; Haney, S. L.; Matthiesen, R. A.; Wiemer, D. F.; Holstein, S. A; Murry, Daryl J. Journal of Pharmaceutical and Biomedical Analysis, 2018, 153, 22-28.  PMID: 29455093
  • α-Methylation Enhances the Potency of Isoprenoid Triazole Bisphosphonates as Geranylgeranyl Diphosphate Synthase Inhibitors.  Mattheissen, R. A.; Varney, M. L.; Xu, P.; Rier, A. S.; Wiemer, D. F.; Holstein, S. A. Bioorg. Med. Chem. 2018, 26, 376-385. PMID: 29248353

2017

  • Olefin Isomers of a Triazole Bisphosphonate Synergistically Inhibit Geranylgeranyl Diphosphate Synthase. Allen, C.;Kortagere, S.; Tong, H.; Mattheissen, R. A.; Metzger, J. I.; Wiemer, D. F.; Holstein, S. A. Mol. Pharm. 2017, 91, 229-236. PMID:    28057800
  • Phosphinophosphonates and their tris-pivaloyloxymethyl prodrugs reveal a negatively cooperative butyrophilin activation mechanism. Shippy, R. R.; Lin, X.; Agabiti, S. S.; Li, J.; Zangari, B. M.; Foust, B. J.; Poe, M. M.; Hsiao, C. C.; Vinogradova, O.; Wiemer, D. F.; Wiemer, A. J. J. Med. Chem., 2017, 60, 2373-2382. PMID:    28218845
  • Bishomoisoprenoid triazole bisphosphonates as inhibitors of geranylgeranyl diphos-phate synthase.  Wills, V. S.; Metzger, J. I.; Allen, C.; Varney, M. L.; Wiemer, D. F.; Holstein, S. A. Bioorg. Med. Chem. 2017, 25, 2437-2444. PMID: 28302510
  • Recent Advances in the Development of Mammalian Geranylgeranyl Diphosphate Synthase Inhibitors. Haney, S. L.; Wills, V. S.; Wiemer, D. F.; Holstein, S. A. Molecules 2017, 22, 886-897. PMID: 28555000
  • Selective opioid growth factor receptor antagonists based on a stilbene isostere. Stockdale, D. P.; Titunick, M. B.; Biegler, J.; Hartung, A. M.; Wiemer, D. F.; McLaughlin, P. J.; Neighbors, J. D.  Bioorg. Med. Chem. 2017, 25, 4464-4474. PMID: 28693915
  • Mixed Aryl phosphonate prodrugs of a Butyrophilin 3A1 ligand. Foust, B. J.; Poe, M. M., N. A., Hsiao, C. C.; Wiemer, A. J.; Wiemer, D. F. ACS Med. Chem. Lett. 2017, 8, 914-918.  Featured article.  PMID: 28947936
  • Synthesis of Amide Isosteres of Schweinfurthin-based Stilbenes.  Stockdale, D. P.; Beutler, J. A.; Wiemer, D. F. Bioorg. Med. Chem. 2017, 25, 5483–5489 (13)  PMID: 28866376

2016

  • Stereoselective Synthesis of Homoneryl and Homogeranyl Triazole Bisphosphonates. Mattheissen, R. A.; Wills, V. S.; Metzger, J. I.; Holstein, S. A.; Wiemer, D. F. J. Org. Chem. 2016, 81, 9438–9442. PMID: 27648672
  • A New Motif for Inhibitors of Geranylgeranyl Diphosphate Synthase. Foust, B. J.; Allen. C.; Holstein, S. A.; Wiemer, D. F. Bioorg. & Med. Chem. 2016, 24, 3734-3741. PMID: 27338660
  • Stereocontrolled regeneration of olefins from epoxides. Wills, V. S.; Zhou, X.; Allen, C.; Holstein, S. A.; Wiemer, D. F. Tetrahedron Lett. 2016, 57, 1335–1337. PMID: 26955189
  • Selective Prenylation of Protected Phenols for Synthesis of Pawhuskin A Analogues. Gardner, K. D.; Wiemer, D. F. J. Org. Chem. 2016, 81, 1585–1592. PMID: 26771823
  • Evaluation of a 7-methoxycoumarin-3-carboxylic acid ester derivative as a fluorescent, cell-cleavable, phosphonate protecting group . Wiemer, A. J.; Shippy, R. R.; Kilcollins, A. M.; Li, J.; Hsiao, C. C.; Barney, R. J.; Geng, M. L.; Wiemer, D. F. ChemBioChem, 2016, 17, 52–55. PMID: 26503489

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