Understanding the chemical perspectives of enzymes and their medical applications

Press Exposure

Humans versus Pathogens” by David Hopper in Academic Minute (Inside Higher ED), April 21, 2016.



Targeting TMP” By Selina Koch, Staff Writer, published in BioCentery, March 3, 2016.


An unprecedented mechanism of nucleotide methylation in organisms containing thyX., Science (New York), 2016 (DOI:10.3410/f.726107361.793514360), has been recommended in F1000Prime as being of special significance in its field by F1000 Faculty Member Victor Davidson.

“UI chemists uncover how key agent allows diseases to reproduce” by Richard C. Lewis: http://now.uiowa.edu/2016/01/ui-chemists-uncover-key-agent Iowa Now Jan 28, 2016. 

Coverage in Advances in Engineering of our Singh, P., Sen, A., Francis, K., Kohen, A.,* “Extension and limits of the network of coupled motions correlated to hydride transfer in dihydrofolate reductase”, J. Am. Chem. Soc., 2014, 136, 2575–2582:

ACS Journal Biochemistry highlighted our recent work on the "Development of PET Probe for Pancreatic Cancer Imaging".

Cover Image of Journal of Computational Chemistry-Roston, D., Kohen, A., Doron, D., Major, D.T., J. Comput. Chem. 2014, 35, 1411-1417.

Understanding Evolution of Single Enzyme Dihydrofolate Reductase from E.coli to Humans- SciGuru

UI researcher studies evolution on the molecular level- Findings may be useful in design of future drugs and catalysts

A fast chemoenzymatic synthesis of [11C]-N5,N10-methylenetetrahydrofolate as a potential PET tracer for proliferating cells -in Global Medical Discovery

Closing in on a Means to Inhibit FDTS Enzymes” Stanford Synchrotron Radiation Lightsource (scientific highlight), September 2012 

Antibiotic target Nature Structural Genomics PSI-SGKB [doi:10.1038/fa_psisgkb.2009.33] Research Advances http://kb.psi-structuralgenomics.org/update/2009/08/full/fa_psisgkb.2009.33.html, July 16, 2009.

Enzymes' Many Movements, C&EN 2009, 87 (17), 34-36 (Click here to download the pdf file of this news)

Novel Mechanisam for DNA Biosynthesis in Organisms with Gene thyX Could ead to Better Antibiotics, Stanford Synchrotron Radiation Lightsource(scientific highlight), April 27, 2009

New Chemical Reaction For DNA Production In Bacteria And Viruses Has Potential For Development Of New Antibacterial And Antiviral DrugsMedical News Today, April 18, 2009 (linked from Medical New Today and MediLexicon)

Scientists discover new chemical reaction for DNA production in bacteria and virusesEurekAlert, Public Release: April 16, 2009

Scientists discover new chemical reaction for DNA production in bacteria and virusesNational Science Foundation News, Press Release 09-072, April 16, 2009

UI chemists' DNA biosynthesis discovery could lead to better antibioticsEurekAlert, Public Release: April 16, 2009

Biochemistry: Anchors away, Maria Paola Costi & Stefania Ferrari, Nature 2009, 458, 840-841

UI chemists' DNA biosynthesis discovery could lead to better antibioticsUniversity of Iowa News Release, April 15, 2009

"Isotope Effects in Chemistry and Biology Edited by Amnon Kohen (University of Iowa) and Hans-Heinrich Limbach (Freie UniversitŠt Berlin)". CRC Press/Taylor and Francis Group: Boca Raton, FL; 2006; 1074 pp; $229.95; ISBN 0-9247-2449-6", Huskey, W. P., J. Am. Chem. Soc.; (Book Review); 2006; 128 (32); 10631-10631.

FAD stage down to the dumps: Exploring the mechanism of a thymidylate synthase, Warfield, R., Chemical Biology, 2006, vol. 1, page B19, Royal Society of Chemistry Publishing.

Quantum catalysis in enzymes: beyond the transition state theory paradigm. A Discussion Meeting held at the Royal Society on 14 and 15 November 2005Nigel S. Scrutton, Michael J. Sutcliffe, and P. Leslie Dutton, J. R. Soc. Interface, published on-line 3/21/2006

Much ado about enzyme mechanisms, Borman, S.Chem. Eng. News 2004, February 23, 35-39

Enzyme Dynamics, Wilson E.K. Chem. Eng. News 2000, July 17, 42-45.